Galaxy Therapeutics Inc. (Milpitas, CA)

A device to treat an aneurysm within the blood vessel is comprised of a wire that is inserted into a tube along with an obstruction element. The cover and the anchoring element of the occlusion element are included. The tube has been designed to fit the occlusion element and allow it to slide out through an opening in the distal edge of the tube when the wire is moved. The cover can expand to an expanded form as it advances to an aneurysm. Its diameter is greater than the neck part of an aneurysm. The cover’s inner anchoring member extends beyond the cover and is designed to touch the aneurysm’s interior surface.

Aneurysms are abnormal expansion or weakening of the blood vessel, usually an artery. They can have many complications. Aneurysms may cause damage to tissues or increase pressure on the surrounding tissues by expanding blood vessels. In the brain, this may result in a variety ofside effects, such as diminished vision, impaired speech or balance impairment, etc. An aneurysm also creates volumes that are not part of the main blood flow path via the blood vessel. It can therefore serve as an area where blood become stagnant, and due to the eddy currents that swirl, could result in the formation of a bleeding thromboembolism. Aneurysms can rupture , causing serious internal bleeding.

The use of open surgery is to treat aneurysms that are externally. These procedures usually involve closing off the opening or “neck” of the aneurysm using an instrument like a the vascular clamp or the Ligature. But, open surgical procedures are often highly surgically invasive, and can result in injuries to adjacent tissue and other side effects.

Aneurysms are also treated through endovascular procedures. A common procedure is to insert coils that can be detachable into the inside of the aneurysm using the catheter. The coils are designed to fill in the size of theaneurysm to decrease blood flow through the aneurysm, inducing stagnation of flow and stimulate clotting within the aneurysm. In the case of massive cerebral aneurysms, filling of the aneurysm using multiple coils can lead to mass effect that mayinduce brain swelling and be an independent cause for new symptoms. Another procedure is for aneurysms that have a large neck, the use of stents assists with the retention of coils within the aneurysm. This approach has acontraindication to being used when treating ruptured aneurysms due to the need for other anti-thrombotic drugs. In a different procedure the coils are held in the volume of the aneurysm using an inflatable balloon that is inflated in the bloodvessel. When the coil mass is secured, the balloon is deflated. Another method is the stent device is inserted in the artery to promote circulation of blood over the aneurysm. This results in thrombosis and stagnation within the aneurysm. However, a side branch of the main arterial vein in which the stent device is placed could become blocked or “jailed”, which impedes access to the side branch. In other situations, the side branch can be blocked, possibly causing stroke. The use of anti-thrombotic medications is mandatory for this procedure. This limits the use of stents in treating ruptured aneurysms. The stent device is generally made up of a fairly tightly weave. The tight weave improves the efficiency of the device in diverting blood flow. However, it can also hinder or prevent the flow to the volume or jailed vessel. In the event that the aneurysmfails to clot, the obstruction of the aneurysm caused by the stent device will prevent the possibility of implanting embolic devices inside the aneurysm. The residual could require further procedures, including open surgery or the installation of other devices.

All procedures that involve filling the volume of the aneurysm have a number of common issues. The first is that it may require many coils of wire to fill the volume of the aneurysm. This is time consuming and increases the amount of time required to complete the procedure. Additionally, the coils could be compacted over time to take up less of the volume of the aneurysm. A high degree of compression of the coils may indicate a recurrence and may need further treatment.

It is beneficial to have a better procedure and treatment for an aneurysm.

One embodiment is a catheter that can be used to treat an aneurysm within a blood vessel. The catheter consists of an elongated tube and an inserted wire into it. It also functions as an obstruction device. The wire is covered by the obstruction elements. The occlusion element is designed to fit inside the tube, and to slide through an opening on the its distal edge as a result of movement of the wire inside the tube. The occlusion element is configured to expand with more than the diameter of the tube and covers an eck portion of the aneurysm.

One example relates to a treatment for an aneurysm in a blood vessel. This involves attaching a wire to an occlusion device in the tube, and then extending an extension tube distal to the neck region. When the tube’s Occlusion element has been removed, the procedure is to separate the occlusion and wire.

One example refers to an occlusion method to treat an aneurysm within blood vessels. The occlusion device comprises a wire, and an occlusion component that is positioned on the wire. The occlusion component is designed to be compressed in a conicalshape and expand in a disk or concave shape for covering a neck portion of an aneurysm.

The invention can be used in other ways. Alternative exemplary embodiments relate to other features and combinations of features as may be generally recited in the claims.

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