INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, NY)
A biosensor consists of the array of nanorods of metal that are positioned on the substrate. A reservoir is constructed between the substrate and an electropolymerized conducting conductor by placing a portion of the nanorods on top it. The pores of the electropolymerized conductor sensitive to electrical signals. Dispensing materials are placed in the reservoir to be dispersed in accordance to open pores.
The invention is generally related to biosensing equipment, and more specifically, devices and methods to control molecular interactions at a device electrode through the release of inhibitors to stop biofouling, or to release growth factor tocontrol cell growth.
Description of Related Art
Biosensors can utilize electrodes to determine the properties of materials as well as to draw attention to substances being measured or sensed. Electrodes employed on biosensors need protection to prevent competing molecules from reacting at the electrodes.Biosensors are useful for detection of neural activity, such as voltage changes around active neurons or the concentration levels of neurotransmitters. Biosensors may have a limited life in vivo because of the possibility of electrochemical fouling due to cellular material accumulation or immune system attack.
In accordance with the embodiment of the invention a biosensor includes the array of metal nanorods placed on a substrate. A conductor that is electropolymerized is formed over tops of at least a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized pores conductor are responsive to electrical signals. The reservoir is filled with a dispensing material to disperse according to open pores.
Another biosensor consists of an array of metal nanorods arranged on a substrate, with the array of metal nanorods is placed into a first and a separate region. The first area has a first spacing among the nanorods so that an electric field not compatible with cell activity can be created upon activation. The second area has a second spacing between the nanorods so that upon activation , an electrical field in line with the activity of cells is produced.
A method for making a biosensor includes forming nanorods in a layer of metal and forming a conformal layer over the nanorods, and recessing the conformal layer onto at least a portion of the nanorods, and then electropolymerizing the conductor over the nanorods exposed by recessing to form a reservoir between an electropolymerized conductor as well as the metal layer the conductor is electropolymerized and has pores that open and close responsively to electrical signals that are applied to the nanorods and loading dispensing material to be dispersed in the reservoir according to the open pores.
These, and other advantages are evident in the thorough description of the illustrated embodiments. This information should be studied in conjunction with accompanying drawings.
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