Essenlix Corporation (Monmouth Junction, NJ)

This invention relates to correction of errors within equipment, operations and operation. through smart monitors, machine learning and various.

Accuracy is crucial when it comes to chemical and biological tests such as a complete blood cell count. However, the errors are unavoidable in instrumentation and operation, particularly, when using low-cost instruments and under resource-limitedconditions. This invention offers instruments and methods that improve the accuracy of image-based biological/chemical analysis of samples.

The following brief summary is not intended to include all the features and characteristics of the invention.

One of the features of the invention a method to enhance imaging-based tests by using a sample hold device equipped with special monitoring mechanisms to assay accuracy and efficiency, error detection, monitoring or any combination thereof.

Another aspect of the present invention is a method of micro-selective-image-assaying (MSIA) that can perform multiple assaying applications on a single image of the sample taken by the imager.

Another feature of the present invention is the ability of detecting monitoring structures and determine their locations from the images of the specimen for assaying and combining machine learning with correction of errors using predetermined characteristics of the structure that are associated with the plurality of the monitored structures.

Another aspect of the present invention is a method to estimate the true-lateral-dimension (TLD) in the image-based assaying, from which the actual dimension or morphological features of the analytes in the image of the sample can be determined.

A method for determining the volume and size of the area-of interest in the image of a sample is a different feature of the invention. This allows for imaging-based assaying to be carried out on any sub-area that is flexible and granular.

Another feature of the invention concerns the evaluation of the performance of the sample-holding device and sample preparation using an image-based test based on images of monitoring structures within the device holding the sample.

Another feature of the present invention is a method for using the monitoring structures that are predesigned in the sample holding device to adjust the imager’s operation in the process of image-based assaying.

A further aspect of the invention is a method for eliminating foreign objects or imperfections from the image-based test using the image of the sample that was taken by the imager.

Another aspect of the invention is a method of developing machine learning models to be used in image-based assay that utilize intelligent monitoring structures in which two strategies that are based on the original image of the sample as well as on the sample images that have been transformed are described.

Another feature of the present invention is the actual application instance of imaging-based assaying for red blood cells in a complete blood count (CBC) by using the methods and algorithms described in the present invention.

A method of using an apparatus to improve imaging-based assays, comprising: (a) having a sample holder, comprising the first plate and second plates that face each other and a plurality of monitoring structures on a sample contact surface of oneor both plates, wherein the monitoring structures have at least one predesigned and predetermined parameter of geometry and/or an optical property, wherein the sample contact surface contacts a sample; (b) sandwiching a sample that contains or issuspected of containing an analyte between the respective sample contact surfaces of the two plates to form a thin layer of 200 .mu.m thick or less, wherein the sample on the sample contact surface is mixed and reacts with a reagent), and wherein thesandwiching, mixing, or reacting is susceptible an error; (c) imaging, using an imager, the sample and the monitoring structures on the sample contact area together, wherein the imager is susceptible to a defect in imaging, and wherein the imagingoperation is susceptible an error; and (d) analyzing the images taken in step (c), using an algorithm, to detect a parameter related to the analyte, wherein the analysis comprises comparing the images with the at least one predesigned and predeterminedparameter and detecting and/or correcting the defect and errors using the at least one predesigned and predetermined parameter.

Click here to view the patent on USPTO website.

Get Patents with PatentPC

What is a patent?

Patents are issued by the government to protect an invention. It gives the inventor the exclusive right to create, use and sell the invention. Society is benefited when new technology is introduced for sale. These benefits could be realized directly as people can achieve previously unattainable feats or indirectly through the economic opportunities which innovation can bring (business expansion, job creation).

Many pharmaceutical firms and university researchers are seeking patent protection for their research and development. Patents may cover an abstract or physical product or process, or even the method or composition of material new to the field. Patent protection is granted to an invention that is beneficial unique, innovative, and not yet known by other people in the same field.

Patents are awarded to inventors who have commercially successful inventions. They provide a reason for inventors to create. Patents allow inventors and small businesses to know that there’s an excellent chance that they will be paid back for their time, effort and investment in the development of technology. This means they will be able to earn a living from their work.

Patents play a vital role in firms and can be used to:

Secure innovative products and services;

Increase the value, appearance, and visibility of your products market

Your business and your products should be distinguished from others;

Get business and technical details.

Beware of the possibility of accidentally using proprietary third-party content, or losing valuable information, innovative outputs, or another creative output.

Patents transform inventor’s knowledge into a marketable asset, which creates new opportunities for employment creation by licensing joint ventures and joint ventures.

Small companies that have patent protection are more attractive to investors involved in the development and commercialization of technology.

Patents can help develop new ideas and inventions. This information can encourage creativity and could be eligible to be protected by patents.

Patents can serve as a deterrent to untrustworthy third parties profiting from the invention’s success.

Commercially successful patent-protected technology revenues can be used to finance technological research and development (R&D) that will increase the chance of better technology in the near future.

You can use the ownership of intellectual property to convince investors and lenders that your product has real commercial potential. One patent that is powerful could lead to numerous financing options. Patents as well as other IP assets can be used as collateral or as security to finance debt. Investors can also see your patent assets to boost the value of their company. Forbes and other publications have reported that each patent can add anywhere from $500,000 to one million dollars to company valuation.

A well-designed business plan is essential for start-ups. It must be founded on IP and show what your service or product stands out. Investors will also be impressed when you demonstrate you have IP rights are secure or is in the process of becoming secure and they are in line with your business plan.

It is crucial to keep an invention secret until you file for patent protection. A public divulging an invention could often damage its novelty and invalidate it. Pre-filing disclosures, such as for investors, test-marketing or other business partners should be done only after signing a confidentiality agreement.

There are a variety of patents and knowing them is essential to protecting your invention. Utility patents cover the development of new methods and machines. Design patents cover ornamental designs. Utility patents are the most effective to protect the proprietor from copycats and other competitors. Most often they are granted for modifications or improvements to existing inventions. Utility patents also cover enhancements and modifications to existing inventions. For instance, a process patent will cover acts or methods for performing an action, while chemical compositions will comprise the combination of ingredients.

How long does a patent last? Although utility patents are valid for 20 years from the date of the initial filing, they can be extended by delays in the patent office.

Do you want to patent your ideas? Patents are granted only to the first applicants to file so you must file quickly. Contact PatentPC today to file your patent application submitted!

When drafting an application for patents it is recommended to conduct an online patent search. it will provide you with an insight into the other applicants’ ideas. You’ll be able to narrow down the nature of your invention. Additionally, you’ll be able to be aware of the current state of technology in your area of invention. This will assist you in know the extent of your invention and prepare you for filing the patent application.

How to Search for Patents

A patent search is the initial step towards obtaining your patent. You can do a google patent search or do a USPTO search. Once the patent application is filed, the item subject to the patent can be referred to as patent-pending and you can locate the patent application on public pair. Once the patent office has approved your application, you will be able do a patent number search to locate the patent issued. Your product now has the potential to be patentable. You can also utilize the USPTO search engine. See below for details. For assistance, you can consult an attorney who is a patent or patent attorney. Patents granted in the United States are granted by the US trademark and patent office as well as the United States patent office. The office also examines trademark applications.

Are you interested in finding similar patents? These are the steps to follow:

1. Brainstorm terms to describe your invention according to its function, composition, or use.

Write down a short detailed description of the invention. Do not use generic terms such as “device,” “process,” and “system.” Instead, think about synonyms for the terms you selected initially. Next, note important technical terms and keywords.

Use the questions below to help you determine key words or concepts.

  • What is the goal of the invention? Is it a utilitarian device or an ornamental design?
  • Does the invention consist of a method of creating something or performing a function? Is it a product or procedure?
  • What is the composition and function of the invention? What is the physical constitution?
  • What is the purpose of this invention?
  • What are technical words and terms that describe the nature of an invention? A technical dictionary can help you locate the right phrases.

2. Utilize these terms to locate relevant Cooperative Patent Classifications on the Classification Text Search Tool. If you’re not able to determine the correct classification for your invention, look through the classification’s class Schemas (class schedules). If you do not get results from the Classification Text Search, you may want to consider replacing the words that describe your invention with synonyms.

3. Go through 3. Check the CPC Classification Definition for confirmation of the CPC classification you’ve found. If the classification you have selected has a blue box with the letter “D” at its left, clicking on the link will lead you to a CPC classification’s description. CPC classification definitions can help you determine the applicable classification’s scope, so you can select the most relevant. Furthermore the definitions may include search tips and other suggestions that may be useful for further study.

4. Find patent documents that have the CPC classification from the Patents Full-Text and Image Database. By focusing on abstracts and illustrations you can narrow your search for the relevant patent documents.

5. Take advantage of this list of most pertinent patent documents to examine each one thoroughly for any similarities to your own invention. Pay attention to the claims and specifications. You may find additional patents by referring to the patent examiner as well as the applicant.

6. Find patent applications published in the public domain using the CPC classification you picked in Step 3 of the Applications Full-Text and Image Database. It is possible to use the same strategy of searching in Step 4 to narrow your search results to the most relevant patent application by looking at the abstract and drawings that appear on each page. Then, you must carefully review the patent applications published with particular attention paid to the claims as well as additional drawings.

7. You can search for other US patent publications by keywords in the AppFT and PatFT databases, and also classification searching of patents not from the US according to below. Additionally, you can use web search engines to find non-patent literature disclosures about inventions. Here are some examples:

  • Add keywords to your search. Keyword searches may turn up documents that are not well-categorized or have missed classifications during Step 2. For example, US patent examiners often supplement their classification searches with keyword searches. Think about the use of technical engineering terminology rather than everyday words.
  • Search for foreign patents using the CPC classification. Then, re-run the search using international patent office search engines such as Espacenet, the European Patent Office’s worldwide patent publication database of over 130 million patent publications. Other national databases include:
  • Search non-patent literature. Inventions can be made public in many non-patent publications. It is recommended that you search journals, books, websites, technical catalogs, conference proceedings, and other print and electronic publications.

To review your search, you can hire a registered patent attorney to assist. A preliminary search will help one better prepare to talk about their invention and other related inventions with a professional patent attorney. In addition, the attorney will not spend too much time or money on patenting basics.